circRNA basic information
circBase ID: hsa_circ_100219
Name: hsa_circ_FAF1
Synonym: Circ-FAF1
Host Gene: FAF1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

serum
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: -
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; ROC Analysis
Clinical significance:

Diagnostic biomarker potential in serum; ROC AUC 0.787 for breast cancer detection; combined with Circ-ELP3 improves AUC to 0.891
Description:

In this case-control cohort, serum Circ-FAF1 (hsa_circ_100219) is reduced in pre-treatment breast cancer patients and increases after treatment. It has diagnostic value by ROC analysis and enhances diagnostic performance when combined with Circ-ELP3.
Confidence score:

0.4187
Other information
Title:

Serum Circ-FAF1/Circ-ELP3: A novel potential biomarker for breast cancer diagnosis.

Journal: Journal of clinical laboratory analysis
Published: 2021
PubMed ID: 34545638
Study type:

clinical study
Data availability: The data that support the findings of this study are available from the corresponding author upon reasonable request.
Code availability: -