| Expression pattern: |
DN |
| Associated gene: |
- |
| Associated microRNA: |
miR-124-3p, miR-204-5p, miR-1248, miR-204-3p |
| Biological function: |
may be involved in maintaining docetaxel sensitivity |
| Molecular mechanism: |
predicted miRNA sponge interactions (e.g., miR-1248, miR-204-5p/3p, miR-124-3p); pathway-level association with PI3K-Akt and AGE-RAGE signaling based on target enrichment of eligible miRNAs |
| Biological pathway or process: |
ceRNA regulation (other); PI3K/AKT (other) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; Back-Splice Junction PCR / divergent primers PCR; RT-qPCR; Sanger Sequencing; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
circEPHA3.2 is strongly down-regulated in docetaxel-resistant breast cancer cell lines. It is predicted to interact with chemotherapy-associated miRNAs (including miR-1248, miR-204-5p/3p, and miR-124-3p) and may help maintain docetaxel sensitivity, with broader pathway associations inferred from miRNA target enrichment (PI3K-Akt and AGE-RAGE). |
| Confidence score: |
0.4761 |