| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
promotes migration and metastasis |
| Molecular mechanism: |
Knockdown of hsa_circ_0079480 suppresses metastatic phenotypes without affecting host gene expression; specific downstream mechanism not defined. |
| Biological pathway or process: |
migration (promotes); metastasis (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; Bioinformatics Analysis; RT-qPCR; Clinical Sample Validation; Cohort Study; Survival Analysis; ROC Analysis; Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; Transfection; Transwell Assay; In Vivo Animal Model; H&E Staining |
| Clinical significance: |
Included in a four-circRNA-based cirScore that stratifies recurrence risk and is associated with shorter DFS and OS in high-risk (high cirScore) patients. |
| Description: |
hsa_circ_0079480 is overexpressed in recurrent stage II/III colon cancer and promotes metastatic behaviors. Knockdown suppresses migration in vitro and reduces liver and lung metastasis in nude mouse xenograft models; it is also part of a four-circRNA cirScore associated with worse survival when high. |
| Confidence score: |
0.8197 |