circRNA basic information
circBase ID: -
Name: hsa_circ_STRBP
Synonym: hsa_circRNA_104907
Host Gene: STRBP
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0008608
MONDO name: Down syndrome
Disease details: Down's syndrome
Disease DO ID:
 14250
Disease MeSH ID:
 D004314
Disease NCIt ID:
 C2993
Disease ICD11 ID:
 1624623908
Disease OMIM ID:
 190685
Species: Human
Species details: Homo sapiens
Tissue specimen:

umbilical cord blood; peripheral blood
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: STRBP
Associated microRNA: -
Biological function: unknown
Molecular mechanism: circRNA/miRNA/mRNA interactions (general; not specified for this circRNA)
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Clinical Sample Validation
Clinical significance:

-
Description:

hsa_circRNA_104907 is downregulated in DS based on cord blood circRNA microarray and was validated by RT-qPCR in peripheral blood from children. It is associated with the host gene STRBP, but the study does not report specific miRNA partners or a detailed mechanism for this circRNA.
Confidence score:

0.3588
Other information
Title:

Differential expression profile study and gene function analysis of maternal foetal-derived circRNA for screening for Down's syndrome.

Journal: Experimental and therapeutic medicine
Published: 2020
PubMed ID: 32010263
Study type:

combined biological and clinical study
Data availability: available from the corresponding author on reasonable request
Code availability: -