circRNA basic information
circBase ID: hsa_circ_0006743
Name: hsa_circ_JMJD1C
Synonym: circJMJD1C
Host Gene: JMJD1C
Genomic location(hg19): chr10:65140077-65140242:-
Genomic location(hg38): chr10:63380317-63380482:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004658
MONDO name: breast carcinoma in situ
Disease details: early-stage breast cancer
Disease DO ID:
 8791
Disease MeSH ID:
 D000071960
Disease NCIt ID:
 C3641
Disease ICD11 ID:
 1264360394
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumour tissue; adjacent normal breast tissue
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: -
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
S
Validation methods:

RNA-seq; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

diagnostic implications in breast cancer
Description:

hsa_circ_0006743 (circJMJD1C) is significantly up-regulated in early-stage breast cancer tissues and was validated by RT-qPCR in clinical samples. The study proposes its potential diagnostic relevance, but does not experimentally define a downstream mechanism or axis for this circRNA.
Confidence score:

0.585
Other information
Title:

Identification of novel dysregulated circular RNAs in early-stage breast cancer.

Journal: Journal of cellular and molecular medicine
Published: 2021
PubMed ID: 33544410
Study type:

combined biological and clinical study
Data availability: SRP156355; PRJNA603126
Code availability: -