circRNA basic information
circBase ID: hsa_circ_0000144
Name: hsa_circ_SLAMF6
Synonym: circSLAMF6
Host Gene: SLAMF6
Genomic location(hg19): chr1:160472466-160472794:+
Genomic location(hg38): chr1:160502676-160503004:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

GC tissues; normal tissues; adjacent normal tissues
Cell lines:

MGC-803; GES-1; AGS
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: DPP6, TPM3, LAMP2, DDX5, NOL11, INTS2, STARD3NL, USP44, GPBP1, VANGL2, TNFRSF21, GPC5, TCF7L2, SIRT1, PPM1D, LMLN, DACH1, MAP1B, SNRNP27, KRAS, EZH2, FOXO3, NR4A2, ADSS, PPP6R3, RANBP1, SRPX2, ATF6B, NUPL2, CACNA1C, IRF2BP2, NUDT7, PGRMC2, TMEM156, SOD2, CYBRD1, DNAJC10, FEN1, CENPA, ELK3, PSME3, PNN, HNRNPC, YWHAH, PRRG4, PIM1, TFAP4, YOD1, SVOP, RAPGEF6, ATP2B1, SREBF1, KPNA6, AP2B1, MAFK, NONO, BTRC, EIF1, MACROD2, B3GALT5, RAB1B, DAZAP2, ODF4, H1F0nn, SRSF2, IDS, KPNA2, NFYB, ARID1A, SLC40A1, NRF1, PCGF3
Associated microRNA: hsa-mir-1178, hsa-mir-1276, hsa-mir-197, hsa-mir-217, hsa-mir-485-3p, hsa-mir-502-5p, hsa-mir-526b, hsa-mir-532-3p, hsa-mir-554, hsa-mir-580, hsa-mir-583, hsa-mir-610, hsa-mir-623, hsa-mir-942
Biological function: promotes GC cell proliferation, migration, and invasion
Molecular mechanism: ceRNA regulatory network of hsa_circ_0000144 targeting miRNAs and mRNAs
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Transfection; CCK8; Transwell Assay; Bioinformatics Analysis
Clinical significance:

might be biomarkers for GC diagnosis and targeted therapy
Description:

hsa_circ_0000144 (circSLAMF6, from SLAMF6) is up-regulated in gastric cancer and promotes GC cell proliferation, migration, and invasion. The study constructed a predicted circRNA-miRNA-mRNA ceRNA network for hsa_circ_0000144 and validated functional effects via siRNA knockdown in GC cell lines.
Confidence score:

0.4852
Other information
Title:

Identification of differentially expressed circRNAs and a novel hsa_circ_0000144 that promote tumor growth in gastric cancer.

Journal: Cancer cell international
Published: 2019
PubMed ID: 31636511
Study type:

combined biological and clinical study
Data availability: GSE78092; 10.1186/s12935-019-0975-y
Code availability: -