circRNA basic information
circBase ID: -
Name: hsa_circ_PRKAR1B
Synonym: AIVR
Host Gene: PRKAR1B
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005812
MONDO name: influenza
Disease details: influenza virus infection
Disease DO ID:
 8469
Disease MeSH ID:
 D007251; D009976
Disease NCIt ID:
 C53482
Disease ICD11 ID:
 145723401
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

A549; HEK293T; MDCK
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: CREBBP
Associated microRNA: miR-330-3p
Biological function: antagonizes influenza virus replication; promotes IFN-beta production
Molecular mechanism: AIVR acts as a miRNA sponge for miR-330-3p, relieving miR-330-3p-mediated repression of CREBBP, thereby increasing CREBBP and facilitating IFN-beta production.
Biological pathway or process:

immune regulation (promotes); ceRNA regulation (promotes)
Detected method:
Q
S
Validation methods:

RNA-seq; Bioinformatics Analysis; RT-qPCR; divergent primers PCR; Sanger Sequencing; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; RNA Pull-Down; Luciferase Reporter Assay; Transfection; Western Blot; ELISA
Clinical significance:

-
Description:

AIVR is a novel human intronic circRNA induced by influenza virus infection in A549 cells. It localizes mainly in the cytoplasm and acts as a miRNA sponge for miR-330-3p, thereby increasing CREBBP expression and enhancing IFN-beta production to antagonize influenza virus replication.
Confidence score:

0.7666
Other information
Title:

A Novel Intronic Circular RNA Antagonizes Influenza Virus by Absorbing a microRNA That Degrades CREBBP and Accelerating IFN-beta Production.

Journal: mBio
Published: 2021
PubMed ID: 34281396
Study type:

biological research
Data availability: GSE172315
Code availability: -