| Expression pattern: |
DN |
| Associated gene: |
NEK2, mTOR, PTEN |
| Associated microRNA: |
- |
| Biological function: |
Tumor suppressor in CRC: inhibits proliferation, colony formation, migration, invasion, and tumor growth in vivo. |
| Molecular mechanism: |
Regulates NEK2 and mTOR (decreases) and PTEN (increases) at mRNA and protein levels; linked to NEK2, mTOR and PTEN signaling pathways. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); PI3K/AKT/mTOR (inhibits); other pathway/process (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Wound Healing Assay; Transwell Assay; In Vivo Animal Model; Western Blot |
| Clinical significance: |
circ-FBXW7 could serve as a target biomarker of CRC; may be a potential therapeutic target for CRC treatment. |
| Description: |
circ-FBXW7 is down-regulated in CRC tissues and functions as a tumor suppressor. Its knockdown promotes CRC cell proliferation/migration/invasion and xenograft growth, while overexpression suppresses these phenotypes, accompanied by decreased NEK2 and mTOR and increased PTEN. |
| Confidence score: |
0.5442 |