| Expression pattern: |
DN |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
Inhibits proliferation, migration, colony formation and tumor growth; enhances sensitivity to 5-fluorouracil and cisplatin. |
| Molecular mechanism: |
Not determined; suggested possibility of acting as a miRNA sponge/ceRNA. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); ceRNA regulation (other); drug resistance (inhibits); chemoresistance (inhibits); invasion (other); metastasis (other); apoptosis (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; ROC Analysis; Transfection; CCK8; Wound Healing Assay; Colony Formation Assay; Annexin V/PI Flow Cytometry; In Vivo Animal Model |
| Clinical significance: |
Low serum circ-BMI1 could distinguish esophageal cancer patients from healthy controls (ROC AUC = 0.726) and was associated with poor differentiation and lymph node metastasis. |
| Description: |
circ-BMI1 (derived from BMI1 exons 6-12) is down-regulated in esophageal cancer tissues and patient serum. Its overexpression in Eca109 cells suppresses proliferation, migration, colony formation and xenograft tumor growth, and increases sensitivity to 5-fluorouracil and cisplatin, suggesting diagnostic and therapeutic potential. |
| Confidence score: |
0.6211 |