| Expression pattern: |
UP |
| Associated gene: |
TCF4, HK2, PKM2, GLUT1, LDHA |
| Associated microRNA: |
miR-140-3p |
| Biological function: |
Promotes osteosarcoma cell proliferation, migration, invasion and glycolysis, and inhibits apoptosis. |
| Molecular mechanism: |
circ_0004674 functions as a miR-140-3p sponge to upregulate TCF4, thereby promoting glycolysis and malignant biological behaviors in osteosarcoma cells. |
| Biological pathway or process: |
glycolysis (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Annexin V/PI Flow Cytometry; Wound Healing Assay; Transwell Assay; Western Blot |
| Clinical significance: |
Potential molecular target for osteosarcoma treatment. |
| Description: |
circ_0004674 is up-regulated in osteosarcoma tissues and cell lines. It promotes glycolysis, proliferation, migration and invasion while suppressing apoptosis through a miR-140-3p/TCF4 ceRNA axis, suggesting potential therapeutic relevance in osteosarcoma. |
| Confidence score: |
0.7177 |