| Expression pattern: |
UP |
| Associated gene: |
MDM2, P53 |
| Associated microRNA: |
miR-1827 |
| Biological function: |
Promotes glioma cell proliferation, migration and invasion; promotes tumor growth in vivo; enhances resistance to TMZ-induced apoptosis (knockdown increases apoptosis). |
| Molecular mechanism: |
Acts as a ceRNA/miRNA sponge for miR-1827 to upregulate MDM2, affecting downstream P53 signaling. |
| Biological pathway or process: |
p53 signaling (other); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
H
|
| Validation methods: |
RT-qPCR; ISH (In Situ Hybridization); FISH / smFISH; Bioinformatics Analysis; Transfection; Luciferase Reporter Assay; MTT; Colony Formation Assay; EdU Staining; Wound Healing Assay; Transwell Assay; Annexin V/PI Flow Cytometry; TUNEL; Western Blot; In Vivo Animal Model; H&E Staining; Survival Analysis; Cohort Study; Clinical Sample Validation |
| Clinical significance: |
High circ_0080229 expression was related to high-grade gliomas and correlated with unfavorable prognosis; proposed as a diagnostic and prognostic biomarker. |
| Description: |
circ_0080229 (EGFR-derived) is up-regulated in glioma tissues and cell lines and mainly localizes in the cytoplasm. It promotes glioma proliferation, migration/invasion and tumor growth by sponging miR-1827, thereby increasing MDM2 and affecting downstream p53 signaling; it is proposed as a prognostic/diagnostic biomarker. |
| Confidence score: |
0.7739 |