circRNA basic information
circBase ID: hsa_circ_0002623
Name: hsa_circ_VANGL1
Synonym: circRNA VANGL1
Host Gene: VANGL1
Genomic location(hg19): chr1:116202261-116206889:+
Genomic location(hg38): chr1:115659640-115664268:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004986
MONDO name: urinary bladder carcinoma
Disease details: bladder cancer
Disease DO ID:
 4007
Disease MeSH ID:
 -
Disease NCIt ID:
 C4912
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

bladder cancer tissues; matched adjacent normal tissues; xenograft tumor tissues
Cell lines:

T24; J82; SV-HUC-1
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: SOX4
Associated microRNA: miR-145-5p
Biological function: promotes viability, inhibits apoptosis, and decreases doxorubicin sensitivity (increases doxorubicin resistance) in bladder cancer cells; promotes tumor growth in vivo
Molecular mechanism: ceRNA mechanism: circ_VANGL1 sponges miR-145-5p, relieving repression of SOX4
Biological pathway or process:

proliferation (promotes); apoptosis (inhibits); drug resistance (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Western Blot; Luciferase Reporter Assay; Transfection; CCK8; Annexin V/PI Flow Cytometry; In Vivo Animal Model; IHC (Immunohistochemistry); Bioinformatics Analysis
Clinical significance:

-
Description:

circ_VANGL1 is up-regulated in bladder cancer tissues and cells. It promotes cell viability and tumor growth, inhibits apoptosis, and reduces doxorubicin sensitivity by sponging miR-145-5p to upregulate SOX4.
Confidence score:

0.6521
Other information
Title:

Circular RNA VANGL1 knockdown suppressed viability, promoted apoptosis, and increased doxorubicin sensitivity through targeting miR-145-5p to regulate SOX4 in bladder cancer cells.

Journal: Open medicine (Warsaw, Poland)
Published: 2021
PubMed ID: 34258391
Study type:

combined biological and clinical study
Data availability: The analyzed datasets generated during the present study are available from the corresponding author on reasonable request.
Code availability: -