circRNA basic information
circBase ID: -
Name: hsa_circ_PRKCI
Synonym: circPRKCI
Host Gene: PRKCI
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004963
MONDO name: T-cell acute lymphoblastic leukemia
Disease details: T-cell acute lymphoblastic leukemia
Disease DO ID:
 5603
Disease MeSH ID:
 -
Disease NCIt ID:
 C3183
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

bone marrow tissues
Cell lines:

MOLT-4; JURKAT
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: SOX4
Associated microRNA: miR-20a-5p
Biological function: promotes T-ALL cell viability and suppresses apoptosis
Molecular mechanism: circPRKCI acts as a ceRNA (miRNA sponge) for miR-20a-5p to promote SOX4 expression
Biological pathway or process:

proliferation (promotes); apoptosis (inhibits); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Annexin V/PI Flow Cytometry; Western Blot
Clinical significance:

-
Description:

circPRKCI is up-regulated in clinical T-ALL bone marrow samples and promotes T-ALL cell survival. Mechanistically, circPRKCI functions as a ceRNA sponging miR-20a-5p, thereby relieving miR-20a-5p-mediated repression of SOX4 and reducing apoptosis.
Confidence score:

0.6479
Other information
Title:

Circular RNA circPRKCI contributes to malignant progression of T-cell acute lymphoblastic leukemia by modulating miR-20a-5p/SOX4 axis.

Journal: Aging
Published: 2021
PubMed ID: 34695805
Study type:

combined biological and clinical study
Data availability: -
Code availability: -