circRNA basic information
circBase ID: -
Name: -
Synonym: HPV31 circE7
Host Gene: -
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0002974
MONDO name: cervical cancer
Disease details: cervical cancer
Disease DO ID:
 4362
Disease MeSH ID:
 -
Disease NCIt ID:
 C9311
Disease ICD11 ID:
 1256072522
Disease OMIM ID:
 603956
Species: Virus
Species details: Human papillomavirus 31
Tissue specimen:

-
Cell lines:

CIN612; primary human foreskin keratinocytes
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: may be regulated by keratinocyte differentiation (decreases upon calcium-induced differentiation)
Molecular mechanism: association with epithelial differentiation state (calcium-induced differentiation reduces circE7 levels)
Biological pathway or process:

other pathway/process (other)
Detected method:
Q
Validation methods:

Back-Splice Junction PCR / divergent primers PCR; RT-qPCR
Clinical significance:

-
Description:

HPV31 circE7 is detectable in HPV31 infection models (HPV31-transfected keratinocytes and CIN612). Its level decreases upon calcium-induced epithelial differentiation, suggesting circE7 is regulated by the differentiation state relevant to the HPV life cycle.
Confidence score:

0.279
Other information
Title:

Transforming activity of an oncoprotein-encoding circular RNA from human papillomavirus.

Journal: Nature communications
Published: 2019
PubMed ID: 31127091
Study type:

biological research
Data availability: -
Code availability: https://github.com/jiwoongbio/vircircRNA