| Expression pattern: |
UP |
| Associated gene: |
RSF1, Ago2 |
| Associated microRNA: |
miR-503-5p |
| Biological function: |
Promotes proliferation, tumor growth and cisplatin/DDP resistance; represses apoptosis; exosomal transfer confers DDP resistance to sensitive cervical cancer cells. |
| Molecular mechanism: |
Exosome-mediated transfer of circSYT15 enhances DDP resistance by acting as a miR-503-5p sponge to upregulate RSF1 expression. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); apoptosis (inhibits); chemoresistance (promotes); drug resistance (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; EdU Staining; Colony Formation Assay; Annexin V/PI Flow Cytometry; RNA Pull-Down; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Bioinformatics Analysis |
| Clinical significance: |
Exosomal circSYT15 is correlated with DDP resistance in CC patients and is elevated in serum exosomes from DDP-resistant patients compared with DDP-sensitive patients. |
| Description: |
circSYT15 is upregulated in DDP-resistant cervical cancer cells and serum/cell-derived exosomes. Exosome-delivered circSYT15 promotes proliferation, tumor growth and cisplatin resistance while inhibiting apoptosis, partly through sponging miR-503-5p and increasing RSF1 expression. Its elevated serum exosomal expression is associated with DDP resistance in cervical cancer patients. |
| Confidence score: |
0.7754 |