circRNA basic information
circBase ID: hsa_circ_0003829
Name: hsa_circ_CASC4
Synonym: -
Host Gene: CASC4
Genomic location(hg19): chr15:44671887-44673174:+
Genomic location(hg38): chr15:44379689-44380976:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004958
MONDO name: oral cavity squamous cell carcinoma
Disease details: oral squamous cell carcinoma
Disease DO ID:
 0050866
Disease MeSH ID:
 -
Disease NCIt ID:
 C4833
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

OSCC tissues; adjacent normal tissues
Cell lines:

HOK; SCC25; SCC15; CAL27
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-1208, hsa-miR-1257, hsa-miR-145, hsa-miR-198, hsa-miR-516b, hsa-miR-580, hsa-miR-587, hsa-miR-7
Biological function: May exert tumor-suppressive effects and may be a diagnostic biomarker in OSCC.
Molecular mechanism: Predicted to act as a ceRNA by binding specific miRNAs (CircInteractome prediction); not experimentally validated.
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

AUC=0.81 for OSCC diagnosis; low expression is negatively correlated with lymph node metastasis and TNM stage.
Description:

hsa_circ_0003829 is significantly down-regulated in OSCC tissues and OSCC cell lines and shows diagnostic potential (AUC 0.81). Bioinformatic prediction suggests it may act as a ceRNA by binding eight candidate miRNAs, though this mechanism is not experimentally validated in the study.
Confidence score:

0.459
Other information
Title:

Hsa_circ_0003829 serves as a potential diagnostic predictor for oral squamous cell carcinoma.

Journal: The Journal of international medical research
Published: 2020
PubMed ID: 32993417
Study type:

clinical study
Data availability: -
Code availability: -