| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
hsa-miR-17-3p, hsa-miR-433-3p, hsa-miR-367-5p, hsa-miR-335-3p, hsa-miR-642a-5p |
| Biological function: |
may be involved in the pathogenesis of sepsis; potential diagnostic biomarker and molecular therapeutic target |
| Molecular mechanism: |
ceRNA mechanism (predicted); miRNA sponge |
| Biological pathway or process: |
ceRNA regulation (other); PI3K/AKT (other); MAPK (other); inflammation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RNase R Treatment; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
ROC analysis showed that hsa_circRNA_104670 in serum exosomes has the potential to be used as a diagnostic marker for sepsis (AUC 0.775). |
| Description: |
hsa_circRNA_104670 is up-regulated in serum exosomes from sepsis patients and shows moderate diagnostic performance by ROC analysis. Bioinformatic prediction suggests it may function as a miRNA sponge (e.g., miR-17-3p) in a circRNA-miRNA-mRNA regulatory network relevant to sepsis-associated inflammatory pathways. |
| Confidence score: |
0.5963 |