circRNA basic information
circBase ID: -
Name: hsa_circ_FNTA
Synonym: circFNTA
Host Gene: FNTA
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

GC samples; corresponding nontumorous tissues; GC tissues; normal tissues
Cell lines:

GES-1; AGS; SGC-7901; BGC-823; MKN-45
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: SCN8A, FNTA
Associated microRNA: miR-604, miR-647
Biological function: circFNTA promotes GC cell proliferation, colony formation, migration, invasion, metastasis, EMT, tumorigenicity, and tumor growth; circFNTA knockdown suppresses proliferative and metastatic capacity.
Molecular mechanism: circFNTA acts as a ceRNA/miRNA sponge for miR-604 and miR-647, thereby increasing SCN8A expression and promoting GC progression through the miR-604/miR-647/SCN8A signaling pathway.
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); EMT (promotes); ceRNA regulation (other); other pathway/process (promotes)
Detected method:
Q
M
Validation methods:

Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; RT-qPCR; Clinical Sample Validation; Luciferase Reporter Assay; RNA Pull-Down; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Wound Healing Assay; Western Blot; In Vivo Animal Model; Survival Analysis; Bioinformatics Analysis
Clinical significance:

High circFNTA expression is positively associated with poor prognosis in GC patients and is significantly correlated with histological grade, lymph node metastasis, distant metastasis, and HP infection; circFNTA is implicated for the diagnosis and treatment of GC.
Description:

circFNTA is upregulated in gastric cancer tissues and cell lines, and high expression is associated with poor patient prognosis. Functionally, circFNTA promotes proliferation, metastasis, EMT and tumor growth. Mechanistically, it sponges miR-604 and miR-647 to upregulate SCN8A, forming the circFNTA/miR-604/miR-647/SCN8A axis.
Confidence score:

0.8298
Other information
Title:

CircFNTA promotes tumorigenesis and progression of gastric cancer via miR-604/miR-647/SCN8A axis.

Journal: Journal of biochemical and molecular toxicology
Published: 2024
PubMed ID: 37942847
Study type:

combined biological and clinical study
Data availability: GSE78092; data available from the corresponding author upon reasonable request
Code availability: -