| Expression pattern: |
UP |
| Associated gene: |
MTDH, Ago2 |
| Associated microRNA: |
miR-127-5p |
| Biological function: |
promotes proliferation and invasion/metastasis; inhibits apoptosis |
| Molecular mechanism: |
ceRNA sponge mechanism: circALPL binds miR-127-5p to upregulate MTDH |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Transfection; CCK8; Annexin V/PI Flow Cytometry; Transwell Assay; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Western Blot; In Vivo Animal Model; H&E Staining; Bioinformatics Analysis |
| Clinical significance: |
circALPL might become a potential biomarker and therapeutic target of gastric cancer. |
| Description: |
circALPL (hsa-circ-0010519), derived from ALPL, is up-regulated in gastric cancer tissues and cell lines and promotes proliferation and invasion/metastasis while suppressing apoptosis. Mechanistically, it mainly localizes to the cytoplasm and functions as a ceRNA by sponging miR-127-5p to increase MTDH expression, forming a circALPL/miR-127-5p/MTDH axis. |
| Confidence score: |
0.7897 |