circRNA basic information
circBase ID: hsa_circ_0043278
Name: hsa_circ_RELN
Synonym: hsa_circRNA_102049
Host Gene: -
Genomic location(hg19): chr17:35797838-35800763:+
Genomic location(hg38): chr17:37437737-37440662:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

HCC tumor tissues; adjacent tissues
Cell lines:

HepG2; Huh-7; HEK-293 T
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: RELN
Associated microRNA: hsa-miR-214-3p
Biological function: Promotes sorafenib sensitivity (reduces proliferation and increases apoptosis) in HCC cells; reverses sorafenib resistance in RELN knockout HCC cells.
Molecular mechanism: Acts as a miRNA sponge for hsa-miR-214-3p to up-regulate RELN expression; affects EMT markers (N-cadherin/E-cadherin) in the context of sorafenib resistance.
Biological pathway or process:

ceRNA regulation (promotes); apoptosis (promotes); proliferation (inhibits); EMT (inhibits); drug resistance (inhibits)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Annexin V/PI Flow Cytometry; Western Blot
Clinical significance:

-
Description:

hsa_circRNA_102049 is down-regulated in sorafenib-resistant HCC cells. Its overexpression increases sorafenib sensitivity by sponging hsa-miR-214-3p to up-regulate RELN, influencing EMT markers and promoting apoptosis while inhibiting proliferation.
Confidence score:

0.593
Other information
Title:

The hsa_circRNA_102049 mediates the sorafenib sensitivity of hepatocellular carcinoma cells by regulating Reelin gene expression.

Journal: Bioengineered
Published: 2022
PubMed ID: 35034536
Study type:

combined biological and bioinformatics study
Data availability: TCGA (https://portal.gdc.cancer.gov/); GSE62813; GSE94550; GSE73571; GSE101850
Code availability: -