| Expression pattern: |
UP |
| Associated gene: |
hexokinase 2 (HK2), HK2 |
| Associated microRNA: |
miR-502-3p |
| Biological function: |
promotes prostate cancer cell proliferation, migration, tumor growth, and lung metastasis; downregulation inhibits malignant progression |
| Molecular mechanism: |
hsa_circ_0006620 acts through the miR-502-3p/HK2 axis to regulate aerobic glycolysis, increasing HK2 expression by sponging miR-502-3p |
| Biological pathway or process: |
ceRNA regulation (promotes); glycolysis (promotes); proliferation (promotes); migration (promotes); metastasis (promotes) |
| Detected method: |
Q
H
S
|
| Validation methods: |
RNase R Treatment; RNA-seq; RT-qPCR; FISH / smFISH; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Transwell Assay; In Vivo Animal Model; IHC (Immunohistochemistry); H&E Staining; ELISA; Western Blot |
| Clinical significance: |
candidate therapeutic marker of prostate cancer |
| Description: |
hsa_circ_0006620 is up-regulated in prostate cancer tissues and cell lines and is localized in the cytoplasm. It promotes prostate cancer proliferation, migration, tumor growth, and lung metastasis by sponging miR-502-3p to increase HK2 expression and enhance aerobic glycolysis. Silencing hsa_circ_0006620 suppresses malignant progression, suggesting the hsa_circ_0006620/miR-502-3p/HK2 axis may be a therapeutic target. |
| Confidence score: |
0.7955 |