| Expression pattern: |
UP |
| Associated gene: |
PTBP1, PKLR |
| Associated microRNA: |
miR-370 |
| Biological function: |
promotes cell proliferation, migration, invasion, tumor growth and Warburg effect; inhibits apoptosis |
| Molecular mechanism: |
circFOXP1 interacts with PTBP1 to enhance PTBP1 binding to PKLR mRNA and protect PKLR mRNA from decay; circFOXP1 sponges miR-370 to upregulate PKLR, promoting glycolysis/Warburg effect |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); glycolysis (promotes); oxidative phosphorylation (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
B
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; Northern Blot; RNase R Treatment; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Cohort Study; Survival Analysis; Transfection; CCK8; Transwell Assay; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Western Blot; IHC (Immunohistochemistry); RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; In Vivo Animal Model |
| Clinical significance: |
circFOXP1 expression was positively associated with lymph node metastasis, advanced TNM stage and poor prognosis; high circFOXP1 was an independent risk factor for overall survival in GBC patients |
| Description: |
circFOXP1 (hsa_circ_0008234) is up-regulated in gallbladder cancer and promotes proliferation, migration/invasion, tumor growth, and aerobic glycolysis while inhibiting apoptosis. It increases PKLR expression by binding PTBP1 to stabilize PKLR mRNA and also functions as a miR-370 sponge to de-repress PKLR, thereby enhancing the Warburg effect and associating with poor overall survival. |
| Confidence score: |
0.8871 |