circRNA basic information
circBase ID: hsa_circ_0062682
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr22:26936754-26937684:-
Genomic location(hg38): chr22:26540788-26541718:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005061
MONDO name: lung adenocarcinoma
Disease details: early-stage lung adenocarcinoma
Disease DO ID:
 3910
Disease MeSH ID:
 C538231
Disease NCIt ID:
 C3512
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

LAC tissues; paired adjacent non-tumorous tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-4268
Biological function: Potentially associated with the development of early-stage LAC.
Molecular mechanism: ceRNA network with predicted miRNA binding (circRNA-miRNA-mRNA).
Biological pathway or process:

Wnt/beta-catenin (other); ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; Bioinformatics Analysis; RT-qPCR; Clinical Sample Validation
Clinical significance:

Might be a potential novel target for the diagnosis of early-stage LAC.
Description:

hsa_circ_0062682 is up-regulated in early-stage lung adenocarcinoma tissues and is highlighted as a potential diagnostic circRNA. Bioinformatic prediction places it in a circRNA-miRNA-mRNA ceRNA network where it interacts with hsa-miR-4268, with downstream genes enriched in Wnt signaling.
Confidence score:

0.4032
Other information
Title:

A circular RNAs dataset landscape reveals potential signatures for the detection and prognosis of early-stage lung adenocarcinoma.

Journal: BMC cancer
Published: 2021
PubMed ID: 34229638
Study type:

combined biological and clinical study
Data availability: GSE101684
Code availability: -