| Expression pattern: |
UP |
| Associated gene: |
Rab23 |
| Associated microRNA: |
miR-362-3p |
| Biological function: |
promotes HCC cell proliferation, invasion, and migration; promotes tumor growth in vivo |
| Molecular mechanism: |
ceRNA mechanism: circMYLK sponges miR-362-3p to up-regulate Rab23 |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
divergent primers PCR; RT-qPCR; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Western Blot; Clinical Sample Validation; In Vivo Animal Model; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High circMYLK expression was associated with poor prognosis and lower survival rate in HCC patients; correlated with extrahepatic metastasis, intrahepatic metastasis and tumor size |
| Description: |
circMYLK is up-regulated in HCC and promotes proliferation, invasion/migration, and xenograft tumor growth. Mechanistically, it acts as a ceRNA to sponge miR-362-3p, relieving repression of Rab23 and activating the miR-362-3p/Rab23 axis, and high circMYLK expression associates with poorer patient survival. |
| Confidence score: |
0.7657 |