circRNA basic information
circBase ID: hsa_circ_0036683
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr15:89656955-89698765:+
Genomic location(hg38): chr15:89113724-89155534:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

HCC tissues; background normal liver tissues; tumour specimens; para-tumour normal background liver tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: -
Molecular mechanism: not specified
Biological pathway or process:

not specified
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Clinical Sample Validation; Survival Analysis; ROC Analysis
Clinical significance:

Low hsa_circ_0036683 expression is associated with poor RFS and OS and is an independent prognostic factor in multivariate analysis; combination with AFP improves AUC for 2-year RFS/OS.
Description:

hsa_circ_0036683 is down-regulated in HCC tissues relative to matched background liver tissues and serves as a prognostic biomarker: low expression predicts worse RFS and OS and remains an independent factor in multivariate models; it also adds predictive value when combined with AFP.
Confidence score:

0.5202
Other information
Title:

Genome-wide identification and characterization of circular RNA in resected hepatocellular carcinoma and background liver tissue.

Journal: Scientific reports
Published: 2021
PubMed ID: 33727578
Study type:

combined biological and clinical study
Data availability: Supplementary material available at 10.1038/s41598-021-85237-y.
Code availability: -