| Expression pattern: |
UP |
| Associated gene: |
HMGB1 |
| Associated microRNA: |
miR-519d-3p |
| Biological function: |
circ_0007385 knockdown suppresses proliferation, migration, invasion, tumor growth, and cisplatin (DDP) resistance; promotes DDP-induced apoptosis/caspase-3 activity. |
| Molecular mechanism: |
Acts as a ceRNA sponge for miR-519d-3p to indirectly regulate HMGB1 expression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); drug resistance (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Survival Analysis; Luciferase Reporter Assay; Transfection; CCK8; Transwell Assay; Western Blot; Annexin V/PI Flow Cytometry; In Vivo Animal Model |
| Clinical significance: |
circ_0007385 expression was associated with poor overall survival in NSCLC patients. |
| Description: |
In NSCLC, circ_0007385 is upregulated and associated with poorer overall survival. Functionally, circ_0007385 promotes malignant behaviors and cisplatin resistance by acting as a ceRNA that sponges miR-519d-3p to upregulate HMGB1, and its knockdown suppresses tumor growth in a xenograft model. |
| Confidence score: |
0.6912 |