| Expression pattern: |
UP |
| Associated gene: |
RAF1, Ago2 |
| Associated microRNA: |
miR-370-3p |
| Biological function: |
promotes proliferation and migration; inhibits apoptosis |
| Molecular mechanism: |
CircAGFG1 sponges miR-370-3p to upregulate RAF1 and activate the RAF/MEK/ERK pathway (ceRNA mechanism). |
| Biological pathway or process: |
RAF/MEK/ERK (promotes); ERK (promotes); proliferation (promotes); migration (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; FISH / smFISH; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; Transfection; CCK8; EdU Staining; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
potential biomarker for diagnosis and therapy in CC treatment |
| Description: |
CircAGFG1 is up-regulated in cervical cancer cell lines and promotes proliferation and migration while suppressing apoptosis. Mechanistically, it functions as a ceRNA by sponging miR-370-3p to relieve repression of RAF1 and activate RAF/MEK/ERK signaling. |
| Confidence score: |
0.6867 |