| Expression pattern: |
UP |
| Associated gene: |
FGFR1, TFF1, Bax, MMP9, GLUT1 |
| Associated microRNA: |
miR-338-3p |
| Biological function: |
Circ-TFF1 promotes breast cancer cell proliferation, invasion, glycolysis and tumorigenesis, and inhibits apoptosis. |
| Molecular mechanism: |
Circ-TFF1 functions as a ceRNA/miRNA sponge for miR-338-3p to positively regulate FGFR1 expression. |
| Biological pathway or process: |
proliferation (promotes); invasion (promotes); glycolysis (promotes); apoptosis (inhibits); ceRNA regulation (promotes); metastasis (promotes) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; Bioinformatics Analysis; Transfection; MTT; EdU Staining; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; IHC (Immunohistochemistry); H&E Staining; In Vivo Animal Model |
| Clinical significance: |
Circ-TFF1 may be a promising therapeutic target or potential new therapeutic strategy for breast cancer. |
| Description: |
Circ-TFF1 is up-regulated in breast cancer tissues and cell lines and acts as an oncogenic circRNA. Mechanistically, cytoplasmic circ-TFF1 sponges miR-338-3p to increase FGFR1 expression, thereby promoting proliferation, invasion, glycolysis and tumor growth while suppressing apoptosis. Its knockdown suppresses breast cancer progression, suggesting therapeutic potential. |
| Confidence score: |
0.8175 |