circRNA basic information
circBase ID: hsa_circ_0029853
Name: hsa_circ_PAN3
Synonym: -
Host Gene: PAN3
Genomic location(hg19): chr13:28830428-28855516:+
Genomic location(hg38): chr13:28256291-28281379:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0011786
MONDO name: allergic rhinitis
Disease details: allergic rhinitis
Disease DO ID:
 4481
Disease MeSH ID:
 -
Disease NCIt ID:
 C79532
Disease ICD11 ID:
 1711769234
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

nasal mucosa tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: ERRFI1, NRCAM
Associated microRNA: hsa-miR-98-5p, hsa-miR-140-5p, hsa-miR-3065-5p
Biological function: promotes AR progression
Molecular mechanism: ceRNA sponging of miRNAs (hsa-miR-98-5p; hsa-miR-140-5p; hsa-miR-3065-5p) to regulate ERRFI1 and NRCAM
Biological pathway or process:

ceRNA regulation (promotes); EGFR (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Sanger Sequencing; divergent primers PCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa_circ_0029853 is down-regulated in allergic rhinitis nasal mucosa and is predicted (via the constructed ceRNA network) to sponge hsa-miR-98-5p/hsa-miR-140-5p/hsa-miR-3065-5p, thereby regulating ERRFI1 and NRCAM, potentially affecting EGFR-related signaling and promoting AR progression.
Confidence score:

0.585
Other information
Title:

CircRNA expression profiles and circRNA-miRNA-mRNA crosstalk in allergic rhinitis.

Journal: The World Allergy Organization journal
Published: 2021
PubMed ID: 34221216
Study type:

combined biological and clinical study
Data availability: available from the corresponding author on reasonable request
Code availability: -