circRNA basic information
circBase ID: -
Name: hsa_circ_CDR1
Synonym: CDR1as
Host Gene: CDR1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

abdominal metastatic nodules
Cell lines:

HGC-27; MGC-803; MKN-45; SGC-7901; BGC-823; AGS; 293T
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UN
Associated gene: GNG7, MMP2, MMP9, E-cadherin, N-cadherin, vimentin
Associated microRNA: miR-876-5p
Biological function: Suppresses gastric cancer cell migration and invasion/metastasis; inhibits EMT and MMP2/MMP9 expression.
Molecular mechanism: Acts as a miR-876-5p sponge to upregulate GNG7, thereby suppressing gastric cancer metastasis.
Biological pathway or process:

migration (inhibits); invasion (inhibits); metastasis (inhibits); EMT (inhibits)
Detected method:
Q
Validation methods:

RT-qPCR; Transfection; Transwell Assay; Luciferase Reporter Assay; Western Blot; Bioinformatics Analysis; In Vivo Animal Model
Clinical significance:

-
Description:

In gastric cancer models, CDR1as suppresses migration, invasion and in vivo metastasis. Mechanistically, it functions as a ceRNA by sponging miR-876-5p to de-repress/upregulate GNG7, leading to inhibition of EMT-associated changes and reduced MMP2/MMP9.
Confidence score:

0.5554
Other information
Title:

Circular RNA CDR1as Inhibits the Metastasis of Gastric Cancer through Targeting miR-876-5p/GNG7 Axis.

Journal: Gastroenterology research and practice
Published: 2021
PubMed ID: 34221006
Study type:

biological research
Data availability: The data used to support the findings of this study are available from the corresponding author request.
Code availability: -