circRNA basic information
circBase ID: hsa_circ_0000423
Name: hsa_circ_PPP1R12A
Synonym: circ_0000423
Host Gene: PPP1R12A
Genomic location(hg19): chr12:80180153-80183460:-
Genomic location(hg38): chr12:79786373-79789680:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumorous tissues; adjacent non-tumorous tissues / para-tumorous tissues
Cell lines:

HGC-27; AGS; MGC-803; MKN-45; GES-1; 293 T
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: DIXDC1
Associated microRNA: miR-582-3p
Biological function: promotes gastric cancer cell proliferation/viability, migration and invasion
Molecular mechanism: circ_0000423 acts as a ceRNA/miRNA sponge for miR-582-3p to regulate DIXDC1 expression
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes)
Detected method:
Q
M
Validation methods:

Microarray; Bioinformatics Analysis; RT-qPCR; RNase R Treatment; Sanger Sequencing; Transfection; CCK8; Transwell Assay; Luciferase Reporter Assay; Western Blot; IHC (Immunohistochemistry); Clinical Sample Validation
Clinical significance:

-
Description:

circ_0000423 is up-regulated in gastric cancer tissues and cell lines and promotes GC cell viability/proliferation, migration, and invasion. Mechanistically, it sponges miR-582-3p to de-repress DIXDC1, forming a circ_0000423/miR-582-3p/DIXDC1 ceRNA axis that drives malignant phenotypes.
Confidence score:

0.814
Other information
Title:

Circular RNA circ_0000423 promotes gastric cancer cell proliferation, migration and invasion via the microR-582-3p/Disheveled-Axin domain containing 1 axis.

Journal: Bioengineered
Published: 2021
PubMed ID: 34898351
Study type:

combined biological and clinical study
Data availability: GSE78092; GSE89143; GSE141977
Code availability: -