| Expression pattern: |
UP |
| Associated gene: |
GRK5 |
| Associated microRNA: |
miR-526b-5p |
| Biological function: |
promotes NSCLC cell growth and metastasis; promotes TAX resistance; inhibits apoptosis; promotes tumor growth in vivo |
| Molecular mechanism: |
ceRNA mechanism: circ_0001821 sponges miR-526b-5p to upregulate GRK5 |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); drug resistance (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Survival Analysis; Transfection; Colony Formation Assay; Transwell Assay; CCK8; Annexin V/PI Flow Cytometry; Luciferase Reporter Assay; RNA Pull-Down; In Vivo Animal Model; Western Blot |
| Clinical significance: |
High circ_0001821 expression is associated with lower overall survival rate in NSCLC patients. |
| Description: |
circ_0001821 is up-regulated in NSCLC tissues and cell lines and functions as an oncogenic circRNA. Its knockdown suppresses proliferation/colony formation, migration/invasion, and in vivo tumor growth while increasing paclitaxel sensitivity and apoptosis, mainly by sponging miR-526b-5p to relieve repression of GRK5 (circ_0001821/miR-526b-5p/GRK5 axis). High circ_0001821 expression is associated with poorer overall survival in NSCLC patients. |
| Confidence score: |
0.737 |