circRNA basic information
circBase ID: hsa_circ_0001946
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chrX:139865339-139866824:+
Genomic location(hg38): chrX:140783174-140784659:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small-cell lung cancer
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissues; adjacent tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: Higher tumor circ_0001946 expression correlates with less lymph node metastasis, lower TNM stage, and improved prognosis (DFS and OS) in NSCLC patients.
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

RT-qPCR; RNase R Treatment; Clinical Sample Validation; Cohort Study; Survival Analysis
Clinical significance:

Higher tumor circ_0001946 expression correlates with less lymph node metastasis, lower TNM stage, and independently predicts improved DFS and OS in NSCLC patients.
Description:

In this retrospective NSCLC cohort, circ_0001946 is down-regulated in tumor tissues compared with adjacent tissues. Higher tumor circ_0001946 expression is associated with less lymph node metastasis, lower TNM stage, and better DFS/OS, and remains an independent favorable prognostic factor.
Confidence score:

0.5727
Other information
Title:

Circular RNA_0001946 is insufficiently expressed in tumor tissues, while its higher expression correlates with less lymph node metastasis, lower TNM stage, and improved prognosis in NSCLC patients.

Journal: Journal of clinical laboratory analysis
Published: 2021
PubMed ID: 34216509
Study type:

clinical study
Data availability: -
Code availability: -