| Expression pattern: |
UP |
| Associated gene: |
AGO2, FBXW7 |
| Associated microRNA: |
miR-223-3p |
| Biological function: |
promotes proliferation, invasion, and migration of gastric cancer cells |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-223-3p and is associated with FBXW7 regulation. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
H
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis; ISH (In Situ Hybridization); Clinical Sample Validation; RT-qPCR; Transfection; CCK8; Transwell Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; ROC Analysis; Survival Analysis |
| Clinical significance: |
High hsa_circ_0023642 expression is associated with malignant progression and clinical stage, and predicts poorer overall survival; it is an independent risk factor for OS and shows prognostic/diagnostic value (ROC AUC 0.6422). |
| Description: |
hsa_circ_0023642 is up-regulated in gastric cancer tissues and cell lines and promotes GC cell proliferation, migration, and invasion. It functions as a ceRNA by sponging miR-223-3p and is linked to regulation of FBXW7, and high expression predicts poorer overall survival. |
| Confidence score: |
0.7972 |