circRNA basic information
circBase ID: hsa_circ_0000284
Name: hsa_circ_HIPK3
Synonym: circHIPK3
Host Gene: HIPK3
Genomic location(hg19): chr11:33307958-33309057:+
Genomic location(hg38): chr11:33286412-33287511:+
Subcellular localization: extracellular vesicle
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0018177
MONDO name: glioblastoma
Disease details: Glioblastoma multiforme
Disease DO ID:
 3068
Disease MeSH ID:
 D005909
Disease NCIt ID:
 C3058
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

serum; GBM tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: Diagnostic biomarker for GBM (decreased in serum sEVs); described as oncogenic in GBM cells (background statement).
Molecular mechanism: Not specified in this study for EV-derived circHIPK3 (used as diagnostic marker based on decreased sEV abundance).
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis; ddPCR
Clinical significance:

Less abundant in serum sEVs from GBM patients vs unaffected controls and grade 3 glioma; ROC analysis shows diagnostic ability (AUC 0.855 for GBM vs UC) and improved accuracy in multivariable model with inflammatory ratios.
Description:

Serum small extracellular vesicle-derived circHIPK3 is decreased in GBM patients compared with unaffected controls (and also lower vs grade 3 glioma), and its ddPCR level shows diagnostic utility for GBM by ROC analysis.
Confidence score:

0.5047
Other information
Title:

Serum Extracellular Vesicle-Derived circHIPK3 and circSMARCA5 Are Two Novel Diagnostic Biomarkers for Glioblastoma Multiforme.

Journal: Pharmaceuticals (Basel, Switzerland)
Published: 2021
PubMed ID: 34198978
Study type:

combined biological and clinical study
Data availability: Data is contained within the article and supplementary material.
Code availability: -