| Expression pattern: |
DN |
| Associated gene: |
SRSF1, VEGFA mRNA isoform ratio |
| Associated microRNA: |
- |
| Biological function: |
Diagnostic biomarker for GBM; tumor-suppressive in GBM (reported previously by the authors). |
| Molecular mechanism: |
In serum EVs, decreased abundance serves as a diagnostic signal; mechanistically (in prior work), circSMARCA5 physically interacts with SRSF1 via a GAUGAA RNA motif affecting migration and angiogenic potential. |
| Biological pathway or process: |
angiogenesis (inhibits); migration (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis; ddPCR |
| Clinical significance: |
Less abundant in serum sEVs from GBM patients vs unaffected controls and grade 3 glioma; ROC analysis shows diagnostic ability (AUC 0.823 for GBM vs UC) and improved accuracy in multivariable model. |
| Description: |
Serum small extracellular vesicle-derived circSMARCA5 is decreased in GBM patients compared with unaffected controls (and also lower vs grade 3 glioma), and its ddPCR level provides diagnostic discrimination for GBM by ROC analysis. |
| Confidence score: |
0.5047 |