| Expression pattern: |
UN |
| Associated gene: |
MYH9 |
| Associated microRNA: |
miR-124-3p |
| Biological function: |
promotes chondrocyte proliferation and migration; inhibits chondrocyte apoptosis; attenuates IL-1beta-induced chondrocyte injury; promotes cartilage repair; inhibits cartilage degradation |
| Molecular mechanism: |
ceRNA mechanism: circHIPK3 binds miR-124-3p to relieve repression of MYH9, increasing MYH9 expression |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
Nuclear-Cytoplasmic Fractionation; RT-qPCR; Western Blot; Luciferase Reporter Assay; Transfection; EdU Staining; Transwell Assay; Wound Healing Assay; Annexin V/PI Flow Cytometry; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry); Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
promising novel cell-free therapy for treating OA |
| Description: |
In a mouse osteoarthritis model, MSC-derived extracellular vesicles deliver circHIPK3 to chondrocytes, where circHIPK3 mainly localizes in the cytoplasm and functions as a ceRNA. By sponging miR-124-3p, circHIPK3 increases MYH9 expression, promoting chondrocyte proliferation/migration and inhibiting apoptosis, thereby alleviating IL-1beta-induced injury and supporting cartilage repair. |
| Confidence score: |
0.7375 |