circRNA basic information
circBase ID: hsa_circ_0000285
Name: hsa_circ_HIPK3
Synonym: -
Host Gene: HIPK3
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0015459
MONDO name: nasopharyngeal carcinoma
Disease details: nasopharyngeal carcinoma
Disease DO ID:
 9261
Disease MeSH ID:
 D00007727; D000077274
Disease NCIt ID:
 C3871
Disease ICD11 ID:
 1883313543
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

NPC tissues; adjacent tissues; serum
Cell lines:

NP69; HK-1; C666-1; 5-8F; SUNE-1
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: associated with NPC development; involved in radiosensitivity/radioresistance; high expression associated with decreased overall survival
Molecular mechanism: not specified
Biological pathway or process:

radioresistance (promotes); metastasis (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Survival Analysis; Cohort Study
Clinical significance:

significantly increased in NPC tissues and serum; associated with clinicopathological features; may be an independent prognostic factor; predictive biomarker of radiotherapy response
Description:

circRNA_0000285 (HIPK3-derived) is up-regulated in NPC tissues, NPC cell lines, and patient serum, and higher serum levels are linked to radioresistant NPC. High circRNA_0000285 expression is associated with adverse clinicopathological features and poorer overall survival, suggesting it is a prognostic biomarker and may predict radiotherapy response.
Confidence score:

0.4758
Other information
Title:

Upregulation of circRNA_0000285 serves as a prognostic biomarker for nasopharyngeal carcinoma and is involved in radiosensitivity.

Journal: Oncology letters
Published: 2018
PubMed ID: 30405788
Study type:

combined biological and clinical study
Data availability: All data generated or analyzed during this study are included in this published article.
Code availability: -