circRNA basic information
circBase ID: hsa_circ_0082628
Name: hsa_circ_ZC3HAV1
Synonym: circ_0082628 / circZC3HAV1
Host Gene: ZC3HAV1
Genomic location(hg19): chr7:138761031-138764989:-
Genomic location(hg38): chr7:139076285-139080243:-
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer / CRC
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

CRC tissues; normal tissues
Cell lines:

FHC; CW-2; RKO; NCI-H508; 293T
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: TBC1D9, AGO2
Associated microRNA: miR-146b-3p
Biological function: inhibits migration and invasion
Molecular mechanism: ceRNA mechanism: circZC3HAV1 sponges miR-146b-3p to upregulate TBC1D9
Biological pathway or process:

migration (inhibits); invasion (inhibits); ceRNA regulation (other)
Detected method:
Q
Validation methods:

RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; RNA Pull-Down; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; Transwell Assay; Wound Healing Assay; CCK8; Annexin V/PI Flow Cytometry; Bioinformatics Analysis
Clinical significance:

-
Description:

circZC3HAV1 is down-regulated in colorectal cancer cells and suppresses migration and invasion. Mechanistically, it functions as a ceRNA that sponges miR-146b-3p, thereby upregulating TBC1D9 to restrain malignant behaviors.
Confidence score:

0.7909
Other information
Title:

circZC3HAV1 Regulates TBC1D9 to Affect the Biological Behavior of Colorectal Cancer Cells.

Journal: BioMed research international
Published: 2022
PubMed ID: 36164444
Study type:

biological research
Data availability: GSE142837
Code availability: -