circRNA basic information
circBase ID: -
Name: hsa_circ_Samd4a
Synonym: circSamd4a
Host Gene: Samd4a
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005311
MONDO name: atherosclerosis
Disease details: vascular calcification
Disease DO ID:
 1936
Disease MeSH ID:
 D050197
Disease NCIt ID:
 C35768
Disease ICD11 ID:
 109367356
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

plasma; mouse aorta
Cell lines:

HAECs
In vivo animal model:

other disease animal model
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: Biomarker for diagnosing vascular calcification/coronary artery calcification; negatively correlated with calcification score.
Molecular mechanism: Not specified in this study (mechanism not experimentally explored).
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis; In Vivo Animal Model; Western Blot
Clinical significance:

Downregulated in VC/CAC plasma; independent risk factor for VC/CAC; ROC AUC 0.81 for diagnosing VC.
Description:

circSamd4a is significantly downregulated in calcified HAECs, calcified mouse aorta, and in plasma from patients with VC/CAC. Its plasma level is an independent risk factor and negatively correlates with coronary artery calcium score, showing diagnostic value (AUC 0.81) as a biomarker for vascular calcification.
Confidence score:

0.6032
Other information
Title:

CircSamd4: A novel biomarker for predicting vascular calcification.

Journal: Journal of clinical laboratory analysis
Published: 2022
PubMed ID: 34845750
Study type:

combined biological and clinical study
Data availability: The data that support the findings of this study are available on request from the corresponding author.
Code availability: -