circRNA basic information
circBase ID: hsa_circ_0001460
Name: hsa_circ_NEIL3
Synonym: circNEIL3
Host Gene: hsa-miR-432-5p
 
 
 
Disease basic information
DO ID:
 3498
DO name: pancreatic ductal adenocarcinoma
Disease details: pancreatic ductal adenocarcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human PDAC cell lines (BxPC-3, MiaPaca-2, CFPAC-1, PANC-1), human pancreatic ductal epithelial (HPNE) cells
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-432-5p
Biological function: Moreover, we discovered that the circNEIL3/miR-432-5p/ADAR1 axis was correlated with the PDAC clinical stage and overall survival of PDAC patients
Molecular mechanism: circNEIL3/miR-432-5p/ADAR1/GLI1 axis, miRNA sponge
Survival: poor
Supported No.:
 1
Description:

circNEIL3 facilitates the proliferation and metastasis of PDAC through the circNEIL3/miR-432-5p/ADAR1/GLI1/cell cycle and EMT axis and that its expression is regulated by ADAR1 through a negative feedback loop. Therefore, circNEIL3 may serve as a prognostic marker and a therapeutic target for PDAC.
Other information
Title:

CircNEIL3 regulatory loop promotes pancreatic ductal adenocarcinoma progression via miRNA sponging and A-to-I RNA-editing.

Journal: Mol Cancer
Published: 2021/3/23
PubMed ID: 33750389