circRNA basic information
circBase ID: -
Name: hsa_circ_RHOBTB3
Synonym: circRHOBTB3
Host Gene: RHOBTB3
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

HCC tissue; adjacent non-cancer tissues; non-tumor tissues
Cell lines:

SNU-449; SNU-387; THLE-2; SNU-448
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: miR-18a
Biological function: Suppresses HCC cell proliferation
Molecular mechanism: Inhibits miR-18a maturation, decreasing mature miR-18a (not affecting miR-18a precursor), thereby suppressing proliferation
Biological pathway or process:

proliferation (inhibits); ceRNA regulation (other)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Transfection; CCK8
Clinical significance:

-
Description:

circRHOBTB3 is down-regulated in hepatocellular carcinoma tissues and HCC cell lines. Its overexpression suppresses HCC cell proliferation by reducing mature miR-18a levels through inhibition of miR-18a maturation (without changing miR-18a precursor).
Confidence score:

0.4862
Other information
Title:

Circular RNA circRHOBTB3 is downregulated in hepatocellular carcinoma and suppresses cell proliferation by inhibiting miR-18a maturation.

Journal: Infectious agents and cancer
Published: 2021
PubMed ID: 34187598
Study type:

combined biological and clinical study
Data availability: The data that support the findings of this study are available on request from the corresponding author.
Code availability: -