circRNA basic information
circBase ID: -
Name: hsa_circ_DOCK1
Synonym: circRNA DOCK1
Host Gene: DOCK1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

HHL-5; MHCC97-H; SK-Hep-1; Huh-7; Hep3b
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: SMAD2
Associated microRNA: miR-654-5p
Biological function: promotes hepatocellular carcinoma cell proliferation, invasion and migration
Molecular mechanism: ceRNA sponge mechanism: circRNA DOCK1 binds miR-654-5p to regulate SMAD2
Biological pathway or process:

ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Nuclear-Cytoplasmic Fractionation; Transfection; Luciferase Reporter Assay; CCK8; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Western Blot
Clinical significance:

-
Description:

circRNA DOCK1 is up-regulated in hepatocellular carcinoma cell lines and mainly localized in the cytoplasm. It promotes HCC cell proliferation, migration and invasion by sponging miR-654-5p, thereby relieving miR-654-5p-mediated repression of SMAD2 (circRNA DOCK1/miR-654-5p/SMAD2 axis).
Confidence score:

0.5699
Other information
Title:

Interference with circRNA DOCK1 inhibits hepatocellular carcinoma cell proliferation, invasion and migration by regulating the miR-654-5p/SMAD2 axis.

Journal: Molecular medicine reports
Published: 2021
PubMed ID: 34184075
Study type:

biological research
Data availability: The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
Code availability: -