| Expression pattern: |
DN |
| Associated gene: |
KLF7, AGO2 |
| Associated microRNA: |
miR-370-5P |
| Biological function: |
Suppresses HCC progression by inhibiting proliferation, migration and metastasis; suppresses tumor growth in vivo. |
| Molecular mechanism: |
Acts as a miRNA sponge/ceRNA that binds miR-370-5P to regulate KLF7 expression (circUBE2J2/miR-370-5P/KLF7 axis). |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); metastasis (inhibits); EMT (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
H
M
|
| Validation methods: |
Microarray; RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; FISH / smFISH; ISH (In Situ Hybridization); Back-Splice Junction PCR / divergent primers PCR; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; Transfection; CCK8; EdU Staining; Colony Formation Assay; Cell Cycle Assay; Transwell Assay; Wound Healing Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
Downregulated circUBE2J2 was correlated with poorer survival; CircUBE2J2 expression is an independent predictor for overall survival (OS). |
| Description: |
circUBE2J2 (hsa_circ_0009246) is down-regulated in HCC and functions as a tumor suppressor. It mainly localizes to the cytoplasm and acts as a ceRNA by sponging miR-370-5P, thereby relieving repression of KLF7 to inhibit HCC cell proliferation and migration and suppress xenograft tumor growth. Low circUBE2J2 expression is associated with poorer overall survival. |
| Confidence score: |
0.8901 |