| Expression pattern: |
UN |
| Associated gene: |
- |
| Associated microRNA: |
miR-150-5p, miR-194-3p, miR-515-5p |
| Biological function: |
promotes cell migration; little effect on cell proliferation |
| Molecular mechanism: |
may act as miRNA sponge (predicted binding sites for miR-150-5p, miR-194-3p and miR-515-5p) |
| Biological pathway or process: |
migration (promotes); proliferation (other); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
divergent primers PCR; RNase R Treatment; Sanger Sequencing; RT-qPCR; Transfection; Transwell Assay; Wound Healing Assay; MTT; Colony Formation Assay; Western Blot; Flow Cytometry（Non-apoptosis/cycle）; RNA Pull-Down; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
In NSCLC cell models, F-circSR1 (a circular RNA generated from the SLC34A2-ROS1 fusion gene) promotes cell migration but shows little effect on proliferation. The study suggests a possible miRNA-sponge role based on predicted binding sites (miR-150-5p/miR-194-3p/miR-515-5p), but this mechanism was not functionally validated. |
| Confidence score: |
0.7822 |