| Expression pattern: |
DN |
| Associated gene: |
VEZF1, Ago2 |
| Associated microRNA: |
miR-222-3p |
| Biological function: |
Circ_0006768 overexpression attenuates OGD/R-induced HBMEC injuries, restores cell viability, angiogenesis and migration, and reduces pro-inflammatory factor release. |
| Molecular mechanism: |
Circ_0006768 acts as a ceRNA or molecular sponge for miR-222-3p, thereby relieving miR-222-3p-mediated suppression of VEZF1 and increasing VEZF1 expression. |
| Biological pathway or process: |
angiogenesis (promotes); migration (promotes); inflammation (inhibits); ceRNA regulation (other); other pathway/process (inhibits) |
| Detected method: |
Q
M
|
| Validation methods: |
RT-qPCR; Microarray; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; Bioinformatics Analysis; Transfection; CCK8; ELISA; Tube Formation Assay; Wound Healing Assay; Western Blot; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down |
| Clinical significance: |
Circ_0006768 was downregulated in ischemic stroke patient plasma and was proposed as a therapeutic target for ischemic stroke. |
| Description: |
Circ_0006768 is downregulated in ischemic stroke plasma and OGD/R-induced HBMECs. Its overexpression protects HBMECs from OGD/R-induced injury by enhancing viability, angiogenesis and migration while suppressing inflammatory cytokine release. Mechanistically, circ_0006768 sponges miR-222-3p to upregulate VEZF1, suggesting therapeutic potential in ischemic stroke. |
| Confidence score: |
0.7629 |