circRNA basic information
circBase ID: -
Name: hsa_circ_CLK3
Synonym: circCLK3
Host Gene: -
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0000500
MONDO name: tongue squamous cell carcinoma
Disease details: tongue squamous cell carcinoma
Disease DO ID:
 0050865
Disease MeSH ID:
 -
Disease NCIt ID:
 C4648
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

TSCC tissues; tumor tissues; paratumor tissues; matched nontumor tissues; adjacent normal tissues
Cell lines:

CAL27; SCC15; SCC4; HOK
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: PARVA, Ago2
Associated microRNA: miR-455-5p
Biological function: circCLK3 promotes TSCC cell proliferation, migration, invasion, and cell cycle progression; circCLK3 knockdown suppresses proliferation, migration and invasion and induces G0/G1 cell cycle arrest.
Molecular mechanism: circCLK3 functions as a ceRNA/molecular sponge for miR-455-5p to upregulate PARVA in TSCC.
Biological pathway or process:

ceRNA regulation (other); proliferation (promotes); migration (promotes); invasion (promotes); cell cycle (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Transfection; MTT; EdU Staining; Transwell Assay; Cell Cycle Assay; Luciferase Reporter Assay; RNA Pull-Down; RIP (RNA Immunoprecipitation); Western Blot; Bioinformatics Analysis
Clinical significance:

-
Description:

circCLK3 is up-regulated in TSCC tissues and cell lines and acts as an oncogenic circRNA. It promotes TSCC cell proliferation, migration, invasion, and cell cycle progression by sponging miR-455-5p and upregulating PARVA.
Confidence score:

0.7289
Other information
Title:

Circular RNA circCLK3 promotes the progression of tongue squamous cell carcinoma via miR-455-5p/PARVA axis.

Journal: Biotechnology and applied biochemistry
Published: 2022
PubMed ID: 33655541
Study type:

combined biological and clinical study
Data availability: The data that support the findings of this study are available from the corresponding author upon reasonable request.
Code availability: -