circRNA basic information
circBase ID: hsa_circ_0077837
Name: hsa_circ_LIFR
Synonym: -
Host Gene: LIFR
Genomic location(hg19): chr6:131247744-131277639:-
Genomic location(hg38): chr6:130926604-130956499:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005036
MONDO name: gastric adenocarcinoma
Disease details: poorly differentiated gastric adenocarcinoma
Disease DO ID:
 3717
Disease MeSH ID:
 -
Disease NCIt ID:
 C4004
Disease ICD11 ID:
 1855471719
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

PDGA tissues; paired noncancerous tissues; GC tissues; adjacent tissues
Cell lines:

GES-1; MGC803; AGS; SGC7901
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: Promising diagnostic candidate for GC and PDGA with the highest diagnostic power among selected circRNAs.
Molecular mechanism: m6A modification was detected among DECs, but no significant expression-m6A correlation was specifically reported for hsa circ 0077837.
Biological pathway or process:

m6A modification (other); other pathway/process (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Sanger Sequencing; Clinical Sample Validation; ROC Analysis; MeRIP / MeRIP-seq; Bioinformatics Analysis
Clinical significance:

Potential diagnostic marker of GC and PDGA; AUC 0.875 for GC and 0.958 for PDGA.
Description:

hsa_circ_0077837 was down-regulated in PDGA/GC and validated by RT-qPCR. It had the strongest diagnostic performance among the selected circRNAs for both GC and PDGA.
Confidence score:

0.6709
Other information
Title:

Circular RNA expression profile and m6A modification analysis in poorly differentiated adenocarcinoma of the stomach.

Journal: Epigenomics
Published: 2020
PubMed ID: 32657141
Study type:

combined biological and clinical study
Data availability: -
Code availability: -