| Expression pattern: |
UP |
| Associated gene: |
AKT3, Ago2 |
| Associated microRNA: |
miR-610 |
| Biological function: |
Promotes multiple myeloma cell proliferation, migration and invasion, and suppresses apoptosis. |
| Molecular mechanism: |
circ_0000142 functions as a competitive endogenous RNA by sponging miR-610, thereby upregulating AKT3 expression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Bioinformatics Analysis |
| Clinical significance: |
High circ_0000142 expression was associated with higher ISS stage and Durie-Salmon stage in multiple myeloma patients. |
| Description: |
circ_0000142 is up-regulated in multiple myeloma tissues and cell lines and is associated with more advanced ISS and Durie-Salmon stage. Functionally, it promotes MM cell proliferation, migration and invasion while inhibiting apoptosis. Mechanistically, circ_0000142 acts as a ceRNA that sponges miR-610 and increases AKT3 expression, thereby promoting MM progression. |
| Confidence score: |
0.7032 |