| Expression pattern: |
UP |
| Associated gene: |
SRSF2 |
| Associated microRNA: |
miR-599 |
| Biological function: |
Knockdown of circ_0006916 represses HCC cell viability, colony formation, migration and invasion, induces G0/G1 cell cycle arrest and apoptosis, and decreases xenograft tumor growth. |
| Molecular mechanism: |
ceRNA mechanism: circ_0006916 sponges miR-599 to regulate SRSF2 expression. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); cell cycle (inhibits); apoptosis (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Cell Cycle Assay; Annexin V/PI Flow Cytometry; In Vivo Animal Model; Western Blot; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
circ_0006916 is up-regulated in HCC tissues and cell lines. Its knockdown suppresses malignant phenotypes in vitro and tumor growth in a xenograft model by acting as a ceRNA to sponge miR-599 and thereby reduce SRSF2 expression. |
| Confidence score: |
0.7951 |