| Expression pattern: |
UP |
| Associated gene: |
NRBP1, Ago2 |
| Associated microRNA: |
miR-330-5p |
| Biological function: |
Promotes PCa cell proliferation and metastasis (invasion, migration, EMT) and inhibits apoptosis; circLRP6 knockdown suppresses tumor growth and EMT in vivo. |
| Molecular mechanism: |
Acts as a miRNA sponge (ceRNA) for miR-330-5p to prevent degradation of NRBP1 and upregulate NRBP1. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); EMT (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
H
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis; RT-qPCR; RNase R Treatment; ISH (In Situ Hybridization); Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; EdU Staining; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Wound Healing Assay; Western Blot; Luciferase Reporter Assay; RNA Pull-Down; RIP (RNA Immunoprecipitation); In Vivo Animal Model; IHC (Immunohistochemistry); Survival Analysis |
| Clinical significance: |
circLRP6 is highly expressed in PCa tissues, especially in high-grade PCa. |
| Description: |
circLRP6 is up-regulated in prostate cancer tissues and cell lines and promotes proliferation and metastatic phenotypes (invasion, migration, EMT) while inhibiting apoptosis. Mechanistically, circLRP6 sponges miR-330-5p to relieve repression of NRBP1, forming a circLRP6/miR-330-5p/NRBP1 ceRNA axis that also drives tumor growth and EMT in a PC3 xenograft model. |
| Confidence score: |
0.8557 |