| Expression pattern: |
UP |
| Associated gene: |
GPX4, AGO2 |
| Associated microRNA: |
miR-1231 |
| Biological function: |
facilitates malignant progression, promotes proliferation and migration/metastasis, and suppresses ferroptosis in papillary thyroid cancer |
| Molecular mechanism: |
ceRNA sponging of miR-1231 leading to GPX4 upregulation (AGO2-associated RISC involvement) |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); metastasis (promotes); ferroptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Transwell Assay; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Western Blot; In Vivo Animal Model; H&E Staining |
| Clinical significance: |
- |
| Description: |
circKIF4A is up-regulated in papillary thyroid cancer and promotes tumor cell proliferation and migration/metastasis. Mechanistically, it acts as a ceRNA sponge for miR-1231 to relieve repression of GPX4, thereby increasing GPX4 and suppressing ferroptosis. |
| Confidence score: |
0.7983 |